Dojčenie a rozvoj mozgu
Väčšina autorov sa zhoduje v tom, že výživa materským mliekom má pozitívny vplyv na vývoj mozgu a tým aj rozvoj motorických a intelektových schopností. Dojčené deti sa rozvíjajú rýchlejšie po pohybovej stránke, lepšie sa učia a v dospelosti sú inteligentnejšie ako deti kŕmené umelými mliekami. Tento efekt sa zdá byť výraznejší u chlapcov. Mechanizmus tohto pôsobenia doteraz nie je objasnený, uvažuje sa o stimulačnom vplyve unikátneho zloženia mastných kyselín materského mlieka, prípadne pozitívnom dopade menšieho výskytu infekcii u detí.
Pediatrics 1998 Jan;101(1):E9 |
Breastfeeding and later cognitive and academic outcomes.
Horwood LJ, Fergusson DM
Christchurch Health and Development Study, Christchurch School of Medicine, Christchurch, New Zealand.
OBJECTIVE: This study examines the associations between duration of breastfeeding and childhood cognitive ability and academic achievement over the period from 8 to 18 years using data collected during the course of an 18-year longitudinal study of a birth cohort of >1000 New Zealand children. METHOD: During the period from birth to age 1 year, information was collected on maternal breastfeeding practices. Over the period from 8 to 18 years, sample members were assessed on a range of measures of cognitive and academic outcomes including measures of child intelligence quotient; teacher ratings of school performance; standardized tests of reading comprehension, mathematics, and scholastic ability; pass rates in school leaving examinations; and leaving school without qualifications. RESULTS: Increasing duration of breastfeeding was associated with consistent and statistically significant increases in 1) intelligence quotient assessed at ages 8 and 9 years; 2) reading comprehension, mathematical ability, and scholastic ability assessed during the period from 10 to 13 years; 3) teacher ratings of reading and mathematics assessed at 8 and 12 years; and 4) higher levels of attainment in school leaving examinations. Children who were breastfed for >/=8 months had mean test scores that were between 0. 35 and 0.59 SD units higher than children who were bottle-fed. Mothers who elected to breastfeed tended to be older; better educated; from upper socioeconomic status families; were in a two-parent family; did not smoke during pregnancy; and experienced above average income and living standards. Additionally, rates of breastfeeding increased with increasing birth weight, and first-born children were more likely to be breastfed. Regression adjustment for maternal and other factors associated with breastfeeding reduced the associations between breastfeeding and cognitive or educational outcomes. Nonetheless, in 10 of the 12 models, fitted duration of breastfeeding remained a significant predictor of later cognitive or educational outcomes. After adjustment for confounding factors, children who were breastfed for >/=8 months had mean test scores that were between 0.11 and 0.30 SD units higher than those not breastfed. CONCLUSIONS: It is concluded that breastfeeding is associated with small but detectable increases in child cognitive ability and educational achievement. These effects are 1) pervasive, being reflected in a range of measures including standardized tests, teacher ratings, and academic outcomes in high school; and 2) relatively long-lived, extending throughout childhood into young adulthood.
J Hum Lact 1996 Mar;12(1):27-30 |
The effect of exclusive breastfeeding on development and incidence of infection in infants.
Wang YS, Wu SY
Of 145 normal fullterm infants studied during the first year after birth, those exclusively breastfed for the first four months differed significantly from those not exclusively breastfed in physical and behavioral development, and resistance to infection. At four months of age, the mean weight of the exclusively breastfed group was higher (p < 0.05). At one year, the exclusively breastfed group showed more advanced. Personal-Social (p = 0.05) and gross Motor development (p < 0.05) on the Denver Developmental Screening TEst, and lesser cumulative incidence of infectious diseases (p < 0.05). This study demonstrated the beneficial effects of breastfeeding on development and resistance to infection in infants.
Wang YS, Wu SY
Of 145 normal fullterm infants studied during the first year after birth, those exclusively breastfed for the first four months differed significantly from those not exclusively breastfed in physical and behavioral development, and resistance to infection. At four months of age, the mean weight of the exclusively breastfed group was higher (p < 0.05). At one year, the exclusively breastfed group showed more advanced. Personal-Social (p = 0.05) and gross Motor development (p < 0.05) on the Denver Developmental Screening TEst, and lesser cumulative incidence of infectious diseases (p < 0.05). This study demonstrated the beneficial effects of breastfeeding on development and resistance to infection in infants.
Am J Clin Nutr 1999 Oct;70(4):525-35 |
Breast-feeding and cognitive development: a meta-analysis.
Anderson JW, Johnstone BM, Remley DT
Metabolic Research Group, Veterans Affairs Medical Center. jwandersmd@aol.com
BACKGROUND: Although the results of many clinical studies suggest that breast-fed children score higher on tests of cognitive function than do formula-fed children, some investigators have suggested that these differences are related to confounding covariables such as socioeconomic status or maternal education. OBJECTIVE: Our objective was to conduct a meta-analysis of observed differences in cognitive development between breast-fed and formula-fed children. DESIGN: In this meta-analysis we defined the effect estimate as the mean difference in cognitive function between breast-fed and formula-fed groups and calculated average effects using fixed-effects and random-effects models. RESULTS: Of 20 studies meeting initial inclusion criteria, 11 studies controlled for >/=5 covariates and presented unadjusted and adjusted results. An unadjusted benefit of 5.32 (95% CI: 4.51, 6.14) points in cognitive function was observed for breast-fed compared with formula-fed children. After adjustment for covariates, the increment in cognitive function was 3.16 (95% CI: 2.35, 3.98) points. This adjusted difference was significant and homogeneous. Significantly higher levels of cognitive function were seen in breast-fed than in formula-fed children at 6-23 mo of age and these differences were stable across successive ages. Low-birth-weight infants showed larger differences (5.18 points; 95% CI: 3.59, 6.77) than did normal-birth-weight infants (2.66 points; 95% CI: 2.15, 3.17) suggesting that premature infants derive more benefits in cognitive development from breast milk than do full-term infants. Finally, the cognitive developmental benefits of breast-feeding increased with duration. CONCLUSION: This meta-analysis indicated that, after adjustment for appropriate key cofactors, breast-feeding was associated with significantly higher scores for cognitive development than was formula feeding.
J Paediatr Child Health 1999 Feb;35(1):82-5 |
Duration of breast-feeding and Bayley's Mental Developmental Index at 1 year of age.
Paine BJ, Makrides M, Gibson RA
Department of Paediatrics and Child Health, Flinders University of South Australia, Australia.
OBJECTIVE: To examine the association between duration of exclusive breast-feeding and developmental indices in initially breast-fed infants at 1 year of age. METHODOLOGY: A cohort of 96 healthy term infants, aged between 10 and 14 months, were recruited from public immunization clinics and child care centres in southern metropolitan Adelaide. Infants were assessed using the Bayley Scales of Infant Development (Mental and Psychomotor Developmental Indices) within 2 weeks of enrollment. Information regarding duration of breast-feeding was provided retrospectively by the mothers of the infants. Duration of exclusive breast-feeding and socio-demographic variables were used as independent variables to determine their effects on development. RESULTS: Due to a significant interaction between duration of breast-feeding and gender on mental development scores, separate regression models for boys and girls were explored. Duration of breast-feeding significantly predicted mental development scores for boys (partial r2 = 0.14, P < 0.005), but not for girls. Duration of breast-feeding did not predict psychomotor development scores. CONCLUSIONS: These findings deserve further examination in large, prospective studies.
Paediatr Perinat Epidemiol 1997 Oct;11(4):441-50 |
Breast feeding, pacifier use and infant development at 12 months of age: a birth cohort study in Brazil.
Barros FC, Victora CG, Morris SS, Halpern R, Horta BL, Tomasi E
Departamento de Medicina Social, Universidade Federal de Pelotas, RS, Brazil.
Many studies suggest that breast feeding confers developmental and intellectual advantages on children. In a recent study, however, no association was found between breast feeding and intelligence in adult life after adjustment for other variables, and the use of pacifier in infancy was the most important predictor of intelligence. We analysed the associations between breast-feeding duration, pacifier use and suspected developmental delay at 12 months of age in a birth cohort in Pelotas, southern Brazil. All 5304 hospital births occurring during 1993 were studied and a sample was followed up at 1, 3, 6 and 12 months of age. Breast-feeding practices and use of pacifiers were assessed at each visit, as well as suspected developmental delay, measured by the Denver II test. The prevalence of developmental delay was analysed, through logistic regression, according to breast-feeding status and pacifier use, accounting for the possible confounding effect of other variables. The prevalence of suspected developmental delay at 12 months was 34.1%, being slightly higher among children who used pacifiers at 6 months than among non-users (35.3% and 28.7% respectively). There was a marked negative association between breast-feeding duration and developmental delay, with children breast fed for 9 months or more presenting significantly less suspected developmental delay (25.5%) than those breast fed for less than 1 month (42.4%). The effects of multiple variables were tested, and only high parity, smoking during pregnancy, birthweight, gestational age, pacifier use and breast-feeding duration remained significantly associated with suspected developmental delay. The effect of pacifier use, however, disappeared after adjusting for breast-feeding duration, suggesting that breast feeding, and not pacifiers, affects child development.
Barros FC, Victora CG, Morris SS, Halpern R, Horta BL, Tomasi E
Departamento de Medicina Social, Universidade Federal de Pelotas, RS, Brazil.
Many studies suggest that breast feeding confers developmental and intellectual advantages on children. In a recent study, however, no association was found between breast feeding and intelligence in adult life after adjustment for other variables, and the use of pacifier in infancy was the most important predictor of intelligence. We analysed the associations between breast-feeding duration, pacifier use and suspected developmental delay at 12 months of age in a birth cohort in Pelotas, southern Brazil. All 5304 hospital births occurring during 1993 were studied and a sample was followed up at 1, 3, 6 and 12 months of age. Breast-feeding practices and use of pacifiers were assessed at each visit, as well as suspected developmental delay, measured by the Denver II test. The prevalence of developmental delay was analysed, through logistic regression, according to breast-feeding status and pacifier use, accounting for the possible confounding effect of other variables. The prevalence of suspected developmental delay at 12 months was 34.1%, being slightly higher among children who used pacifiers at 6 months than among non-users (35.3% and 28.7% respectively). There was a marked negative association between breast-feeding duration and developmental delay, with children breast fed for 9 months or more presenting significantly less suspected developmental delay (25.5%) than those breast fed for less than 1 month (42.4%). The effects of multiple variables were tested, and only high parity, smoking during pregnancy, birthweight, gestational age, pacifier use and breast-feeding duration remained significantly associated with suspected developmental delay. The effect of pacifier use, however, disappeared after adjusting for breast-feeding duration, suggesting that breast feeding, and not pacifiers, affects child development.
Acta Paediatr 1999 Dec;88(12):1327-32 |
Duration of breastfeeding and developmental milestones during the latter half of infancy.
Vestergaard M, Obel C, Henriksen TB, Sorensen HT, Skajaa E, Ostergaard J
Department of Obstetrics and Gynaecology, Aarhus University Hospital, Denmark.
Several studies have suggested that breastfeeding has a long-term influence on brain development. However, interpretation of these findings is complicated by the presence of many potential confounding factors. Only a few studies have examined infants before 1 y of age, although very early assessment might reduce the role of environmental influence. We investigated the association between exclusive breastfeeding and three developmental milestones related to general and fine motor skills and early language development at the age of 8 mo. We followed 1656 healthy, singleton, term infants, with a birthweight of at least 2500 g, born between May 1991 and February 1992 in Aarhus, Denmark. Information was collected at 16 wk gestation, at delivery and when the infant was 8 mo old. Motor skills were evaluated by measurement of crawling and pincer grip. Early language development was defined as the ability to babble in polysyllables. The proportion of infants who mastered the specific milestones increased consistently with increasing duration of breastfeeding. The relative risk for the highest versus the lowest breastfeeding category was 1.3 (95% CI: 1.0-1.6) for crawling, 1.2 (95% CI: 1.1-1.3) for pincer grip and 1.5 (95% Cl: 1.3-1.8) for polysyllable babbling. Little change was found after adjustment for confounding. In conclusion, our data support the hypothesis that breastfeeding benefits neurodevelopment.
Vestergaard M, Obel C, Henriksen TB, Sorensen HT, Skajaa E, Ostergaard J
Department of Obstetrics and Gynaecology, Aarhus University Hospital, Denmark.
Several studies have suggested that breastfeeding has a long-term influence on brain development. However, interpretation of these findings is complicated by the presence of many potential confounding factors. Only a few studies have examined infants before 1 y of age, although very early assessment might reduce the role of environmental influence. We investigated the association between exclusive breastfeeding and three developmental milestones related to general and fine motor skills and early language development at the age of 8 mo. We followed 1656 healthy, singleton, term infants, with a birthweight of at least 2500 g, born between May 1991 and February 1992 in Aarhus, Denmark. Information was collected at 16 wk gestation, at delivery and when the infant was 8 mo old. Motor skills were evaluated by measurement of crawling and pincer grip. Early language development was defined as the ability to babble in polysyllables. The proportion of infants who mastered the specific milestones increased consistently with increasing duration of breastfeeding. The relative risk for the highest versus the lowest breastfeeding category was 1.3 (95% CI: 1.0-1.6) for crawling, 1.2 (95% CI: 1.1-1.3) for pincer grip and 1.5 (95% Cl: 1.3-1.8) for polysyllable babbling. Little change was found after adjustment for confounding. In conclusion, our data support the hypothesis that breastfeeding benefits neurodevelopment.
Acta Paediatr 1999 Oct;88(10):1101-6 |
Effect of breastfeeding and morbidity on the development of low birthweight term babies in Brazil.
Morris SS, Grantham-McGregor SM, Lira PI, Assuncao AM, Ashworth A
International Food Policy Research Institute, Washington, DC, USA.
Low birthweight (LBW) occurs in 17% of births in developing countries and many of them are full term. The subsequent development of LBW term infants is poorer than higher birthweight children and more likely to be affected by poor social circumstances. We investigated the effects of morbidity and breastfeeding on the development of these LBW term infants. Two parallel cohorts (n = 131 + 131) of LBW term (1500-2499 g) and higher birthweight (3000-3499 g) infants were recruited from six maternity centers in northeast Brazil. The longitudinal prevalence of morbidity and the frequency of breastfeeding over the first 6 mo of life were assessed. The infants' development was assessed on the Bayley Scales at 6 and 12 mo, and we previously reported that the low birthweight group had lower scores than the higher birthweight group. Hospitalizations in the first 6 mo were negatively associated with 6-mo and 12-mo Bayley scores in both groups. Among LBW infants, but not higher birthweight infants, there were significant associations between the prevalence of diarrhea and mental and motor development at 6 mo and mental development at 12 mo. Breastfeeding frequency in the first 4 wk of life was positively associated with mental development in both birthweight groups at 6 mo but not at 12 mo. Breastfeeding beyond 4 wk was not associated with the children's development. We conclude that low birthweight infants are especially vulnerable to the effects of diarrhea, and the greater frequency and differential effect of diarrhea partly explains their poorer development.
Morris SS, Grantham-McGregor SM, Lira PI, Assuncao AM, Ashworth A
International Food Policy Research Institute, Washington, DC, USA.
Low birthweight (LBW) occurs in 17% of births in developing countries and many of them are full term. The subsequent development of LBW term infants is poorer than higher birthweight children and more likely to be affected by poor social circumstances. We investigated the effects of morbidity and breastfeeding on the development of these LBW term infants. Two parallel cohorts (n = 131 + 131) of LBW term (1500-2499 g) and higher birthweight (3000-3499 g) infants were recruited from six maternity centers in northeast Brazil. The longitudinal prevalence of morbidity and the frequency of breastfeeding over the first 6 mo of life were assessed. The infants' development was assessed on the Bayley Scales at 6 and 12 mo, and we previously reported that the low birthweight group had lower scores than the higher birthweight group. Hospitalizations in the first 6 mo were negatively associated with 6-mo and 12-mo Bayley scores in both groups. Among LBW infants, but not higher birthweight infants, there were significant associations between the prevalence of diarrhea and mental and motor development at 6 mo and mental development at 12 mo. Breastfeeding frequency in the first 4 wk of life was positively associated with mental development in both birthweight groups at 6 mo but not at 12 mo. Breastfeeding beyond 4 wk was not associated with the children's development. We conclude that low birthweight infants are especially vulnerable to the effects of diarrhea, and the greater frequency and differential effect of diarrhea partly explains their poorer development.
Early Hum Dev 1997 Oct 29;49 Suppl:S175-84 |
Association between breast feeding, child development and behaviour.
Golding J, Rogers IS, Emmett PM
Unit of Paediatric and Perinatal Epidemiology, University of Bristol, UK.
Consistent data are available to suggest that children who have been breast fed are, on average, intellectually more able than their formula-fed contemporaries. This has been shown in eight of 10 population studies and all three studies of low birthweight infants. In general, the longer the child has been breast fed the more pronounced the effect. There is evidence that breast milk that has been pasteurised before feeding does not have this effect, but that fresh breast milk is effective whether the milk is delivered by tube or by the breast. However no studies have been able to have both sufficient statistical power and the ability to allow for other confounders such as parental ability, parental IQ and other factors that might explain these findings. Additional data from studies of visual acuity show an association between breast feeding and enhanced vision which is hypothesised to be due to the unique fatty acid composition of breast milk. The differences in intellectual development might also be related to these fatty acids. Alternative explanations for the effect on intellectual development concern the possible consequences of early infections, particularly gastroenteritis, which are more common in bottle-fed babies. In contrast with the many publications on cognitive function and breast feeding, there was only one on neurological dysfunction (showing a protective effect of breast feeding) and one on childhood behaviour (using the teacher's assessment no relationship with breast feeding was found). Further research is needed in both areas.
Golding J, Rogers IS, Emmett PM
Unit of Paediatric and Perinatal Epidemiology, University of Bristol, UK.
Consistent data are available to suggest that children who have been breast fed are, on average, intellectually more able than their formula-fed contemporaries. This has been shown in eight of 10 population studies and all three studies of low birthweight infants. In general, the longer the child has been breast fed the more pronounced the effect. There is evidence that breast milk that has been pasteurised before feeding does not have this effect, but that fresh breast milk is effective whether the milk is delivered by tube or by the breast. However no studies have been able to have both sufficient statistical power and the ability to allow for other confounders such as parental ability, parental IQ and other factors that might explain these findings. Additional data from studies of visual acuity show an association between breast feeding and enhanced vision which is hypothesised to be due to the unique fatty acid composition of breast milk. The differences in intellectual development might also be related to these fatty acids. Alternative explanations for the effect on intellectual development concern the possible consequences of early infections, particularly gastroenteritis, which are more common in bottle-fed babies. In contrast with the many publications on cognitive function and breast feeding, there was only one on neurological dysfunction (showing a protective effect of breast feeding) and one on childhood behaviour (using the teacher's assessment no relationship with breast feeding was found). Further research is needed in both areas.
Psychol Rep 1996 Dec;79(3 Pt 2):1179-85 |
Breast feeding and children's intelligence.
Johnson DL, Swank PR, Howie VM, Baldwin CD, Owen M
Department of Psychology, University of Houston, TX 77204-5341, USA.
Breast feeding was reported in 1992 by Lucas, et al. to provide advantages for the development of intelligence in children of low birth weight, possibly through nutrients or other biological factors found in human breast milk but not cow's milk. Research on breast feeding and intelligence in children of normal birth weight has yielded mixed results, probably because measurement of environmental influences has not been thorough and the range of intelligence components measured has been limited. Our research with 204 3-year-old children of normal birth weight included control measures for the environment and maternal intelligence (Hollings-head socioeconomic status, Home Observation for the Measured Environment, Shipley) and two measures of childhood intelligence (Stanford-Binet Fourth Edition and Peabody Picture Vocabulary Test-Revised). Controlling for environmental variables and maternal intelligence, initiation of breast feeding predicted scores on intelligence tests at age three. Breast feeding was associated with 4.6-point higher mean in children's intelligence.
Johnson DL, Swank PR, Howie VM, Baldwin CD, Owen M
Department of Psychology, University of Houston, TX 77204-5341, USA.
Breast feeding was reported in 1992 by Lucas, et al. to provide advantages for the development of intelligence in children of low birth weight, possibly through nutrients or other biological factors found in human breast milk but not cow's milk. Research on breast feeding and intelligence in children of normal birth weight has yielded mixed results, probably because measurement of environmental influences has not been thorough and the range of intelligence components measured has been limited. Our research with 204 3-year-old children of normal birth weight included control measures for the environment and maternal intelligence (Hollings-head socioeconomic status, Home Observation for the Measured Environment, Shipley) and two measures of childhood intelligence (Stanford-Binet Fourth Edition and Peabody Picture Vocabulary Test-Revised). Controlling for environmental variables and maternal intelligence, initiation of breast feeding predicted scores on intelligence tests at age three. Breast feeding was associated with 4.6-point higher mean in children's intelligence.
J Nutr 1995 Aug;125(8 Suppl):2278S-2280S |
Human milk and breast feeding for optimal mental development.
Uauy R, De Andraca I
Instituto de Nutricion y Tecnologia de los Alimentos (INTA), Universidad de Chile, Santiago.
Human milk has been characterized as the optimal food for human growth and development because of its nutritional, antiinfective and biological properties.Research conducted over the past decades provides further evidence on the uniqueness of human milk feeding for optimal brain development. The recognition of specific functions for the long chain essential fatty acids present in human milk as key components of neural membranes necessary for optimal brain development has provided a biological basis for this phenomenon. In addition the act of breast feeding provides unique mother-infant interactions opportunities that may have important implications for infant growth and development. These findings may have special relevance to populations in developing countries because this provides yet other very strong reasons to favor human milk feeding.
Uauy R, De Andraca I
Instituto de Nutricion y Tecnologia de los Alimentos (INTA), Universidad de Chile, Santiago.
Human milk has been characterized as the optimal food for human growth and development because of its nutritional, antiinfective and biological properties.Research conducted over the past decades provides further evidence on the uniqueness of human milk feeding for optimal brain development. The recognition of specific functions for the long chain essential fatty acids present in human milk as key components of neural membranes necessary for optimal brain development has provided a biological basis for this phenomenon. In addition the act of breast feeding provides unique mother-infant interactions opportunities that may have important implications for infant growth and development. These findings may have special relevance to populations in developing countries because this provides yet other very strong reasons to favor human milk feeding.
Early Hum Dev 1998 Jan 9;50(2):209-17 |
Does breast-feeding influence intelligence quotients at 9 and 10 years of age?
Malloy MH, Berendes H
University of Texas Medical Branch, Galveston, USA.
The effect of breast-feeding on intellectual development remains controversial. We explored this relationship in a high socioeconomic population in which breast-feeding was supplemented with soy containing formulas at some time during the first year of life. As part of the 1988 National Institute of Child Health and Human Development school-based survey of two metropolitan Washington, D.C. counties to identify children in the 1978 to 1979 birth cohort who had been exposed to the chloride deficient formulas Neo-Mull-Soy and Cho-Free during infancy, information on breast-feeding was also obtained on children exposed to the chloride-deficient formulas and a group of control children exposed to other soy formulas. Because no differences in intellectual development were observed between the two groups, they were combined and the effect of breast-feeding on intellectual development at 9 and 10 years was assessed. There were 176 infants that received no breast-feeding and 342 who were breast-fed. The median duration of breast-feeding was 124 days (interquartile range, 42-248 days). There were no differences in birth weight, gender or race between the infants who were breast-fed and those who were not. The mean Weschler Intelligence Scale-Revised Full Scale IQ was 122 among those breast-fed compared to 118 among those that were not (P = 0.0008). However, following adjustment by linear regression for maternal education, paternal education and annual income the adjusted mean full scale IQ was 111 among the breast-fed and 110 among the non-breast-fed (P = 0.23). Further analyses limited to those exclusively breast-fed for the first 60 days failed to demonstrate any significant relationship between breast-feeding and IQ.
Malloy MH, Berendes H
University of Texas Medical Branch, Galveston, USA.
The effect of breast-feeding on intellectual development remains controversial. We explored this relationship in a high socioeconomic population in which breast-feeding was supplemented with soy containing formulas at some time during the first year of life. As part of the 1988 National Institute of Child Health and Human Development school-based survey of two metropolitan Washington, D.C. counties to identify children in the 1978 to 1979 birth cohort who had been exposed to the chloride deficient formulas Neo-Mull-Soy and Cho-Free during infancy, information on breast-feeding was also obtained on children exposed to the chloride-deficient formulas and a group of control children exposed to other soy formulas. Because no differences in intellectual development were observed between the two groups, they were combined and the effect of breast-feeding on intellectual development at 9 and 10 years was assessed. There were 176 infants that received no breast-feeding and 342 who were breast-fed. The median duration of breast-feeding was 124 days (interquartile range, 42-248 days). There were no differences in birth weight, gender or race between the infants who were breast-fed and those who were not. The mean Weschler Intelligence Scale-Revised Full Scale IQ was 122 among those breast-fed compared to 118 among those that were not (P = 0.0008). However, following adjustment by linear regression for maternal education, paternal education and annual income the adjusted mean full scale IQ was 111 among the breast-fed and 110 among the non-breast-fed (P = 0.23). Further analyses limited to those exclusively breast-fed for the first 60 days failed to demonstrate any significant relationship between breast-feeding and IQ.
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